In 1927 he married Soong May-ling (later to be known a Madame Chiang Kai-shek) whom he had met in 1920.
She was the sister-in-law of Sun Yat-sen and the daughter of a prominent and powerful Shanghai publishing tycoon.
In 1912, Chiang shot and killed Tao Chengzhang, the leader of the Restoration Society, at point-blank range as Tao lay sick in a Shanghai hospital.
In 1916 Chiang became the leader of the Chinese Revolutionary Party in Shanghai.
Chiang told his future mother-in-law that he could not convert immediately, because religion needed to be gradually absorbed, not swallowed like a pill. Chiang achieved an unsteady national unity In 1928 and was named Generalissimo of all Chinese forces and Chairman of the National Government based in Nanjing.
In the following decade Chiang's government worked to modernize the legal and penal systems, institute Major financial reforms, Improve the educational system, build new highways and railroads, improve public health facilities, legislate against drug trafficking, and augment industrial and agricultural production.
Chiang also established the New Life Movement in 1934 which reasserted traditional Confucian values to combat communist ideas.
After Sun Yat-sen's death in 1925, a brief power struggle with rival Wang Ching-wei ensued.
Chiang emerged from the fray as the Commander-in-Chief of the National Revolutionary Forces.