This sedating activity is sometimes used in managing conditions such as eczema where sleep maybe disturbed due to pruritus.Sedating antihistamines also have significant antimuscarinic activity and should be used with caution in patients with prostatic hypertrophy, urinary retention and angle-closure glaucoma.Histamine is a naturally occurring nitrogen-based chemical that is essential to localized immune responses and various physiological bodily functions, including sleep, sexual activity and much more.The secretion of histamine is stimulated by a wide array of foreign pathogens–think reaction causing stimuli that are transmitted by such things as insect bites, plant pollen, pet dander and many others.This information is provided only to help medical providers and their patients see relative costs.
The most significant advantage of non-sedating antihistamines is just what their mane implies: they do not have a sedative-like effect on the user.
Loratadine does not cross the blood-brain barrier and does not cause central nervous system effects.
A second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria.
Antihistamines are classified into two groups – the first-generation (“sedating”) and second-generation (“non-sedating”).
Sedating antihistamines cause sedation as they are highly lipid soluble and readily cross the blood brain barrier.